Nucleotide inhibition of the pancreatic ATP-sensitive K+ channel explored with patch-clamp fluorometry
Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1).ATP/ADP binding to Kir6.2 shuts KATP.Mg-nucleotide binding to SUR1 stimulates KATP.In the absence of Mg2+, Services SUR1 increases the apparent affinity for nucleotide inhibition at Kir6.2 by an unknown